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DNM1 / Dynamin is a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene Name: | dynamin 1 |
Family/Subfamily: | Dynamin |
Synonyms: | DNM1, Dynamin, Dynamin-1, DNM, Dynamin 1 |
Target Sequences: | NM_004408 NP_004399.2 Q05193 |
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