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Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
Gene Name: | DnaJ (Hsp40) homolog, subfamily C, member 2 |
Synonyms: | DNAJC2, MPHOSPH11, Zuotin-related factor 1, ZUO1, ZRF1, M-phase phosphoprotein 11, MPP11, Zuotin, Zuotin related factor 1 |
Target Sequences: | X98260 CAA66913.1 Q99543 |
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