DMPK / DM

dystrophia myotonica-protein kinase

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

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Products

ELISA Kits (3)

Type

Cell-Based (1)

Competitive EIA (1)

Sandwich (1)

Target

DMPK / DM (3)

Reactivity

Human (2)

Mouse (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

Publications

No (3)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (2)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

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Human DMPK / DM (Sandwich ELISA) ELISA Kit - LS-F49340

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human DMPK / DM (Cell-Based ELISA) ELISA Kit - LS-F3163

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse DMPK / DM (Competitive EIA) ELISA Kit - LS-F49739

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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