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DMPK / DM
dystrophia myotonica-protein kinase
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
| Gene Name: | dystrophia myotonica-protein kinase |
| Family/Subfamily: | Protein Kinase , DMPK |
| Synonyms: | DMPK, DM-kinase, DM1, DM1PK, DM protein kinase, DM1 protein kinase, DMK, MDPK, Myotonic dystrophy kinase, MT-PK, Myotonin kinase, MtPK, Myotonic protein kinase, Myotonin protein kinase A, Thymopoietin homolog, DM, Myotonin-protein kinase |
| Target Sequences: | NM_004409 NP_004400.4 Q09013 |
Publications (1)
1
AON-induced splice-switching and DMPK pre-mRNA degradation as potential therapeutic approaches for Myotonic Dystrophy type 1. Ewa Stepniak-Konieczna, Patryk Konieczny, Piotr Cywoniuk, Julia Dluzewska, Krzysztof Sobczak. Nucleic acids research. 2020 Mar;48:2531-2543. [Full Text Article]
[PubMed:31965181]
[PMC:PMC7049696]
Related Antibodies: LS-C167452.
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DMPK / DM Rabbit anti-Human Polyclonal (aa11-60) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) Antibody
Human
WB
Unconjugated
400 µl/$393
DMPK / DM Rabbit anti-Human Polyclonal (aa323-372) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
DMPK / DM Rabbit anti-Human Polyclonal (aa323-372) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Bat, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
DMPK / DM Rabbit anti-Human Polyclonal (aa323-372) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Bat, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
DMPK / DM Rabbit anti-Human Polyclonal (aa323-372) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Bat, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
DMPK / DM Mouse anti-Human Monoclonal (2F7) Antibody
Human
ELISA, IHC-P, RNAi, WB
Unconjugated
50 µg/$460
DMPK / DM Mouse anti-Human Monoclonal (aa393-543) (12K82) Antibody
Human
WB
Unconjugated
100 µg/$896
DMPK / DM Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DMPK / DM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$749
DMPK / DM Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rat, Human
WB
FITC Conjugated
100 µl/$937
DMPK / DM Rabbit anti-Rat Polyclonal (PE) Antibody
Rat
WB
PE Conjugated
100 µl/$411; 200 µl/$515; 500 µl/$906; 1 ml/$1,071
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Competitive EIA
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
DMPK / DM Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
DMPK / DM Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$786
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
DMPK / DM Rabbit anti-Human Polyclonal (aa11-39) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
DMPK / DM Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
DMPK / DM Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
DMPK / DM Rabbit anti-Human Polyclonal (aa30-79) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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