DMD / Dystrophin

dystrophin

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix.

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Products

ELISA Kits (25)

Type

Competitive EIA (1)

Custom (5)

Sandwich (16)

Sandwich CLIA (3)

Target

DMD / Dystrophin (25)

Reactivity

Human (5)

Mouse (6)

Rat (5)

Chicken (2)

Dog (1)

Guinea pig (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Sheep (1)

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Format

12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (20)

Publications

No (25)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (12)

Serum (12)

Tissue Homogenates (5)

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Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F4776

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F11308

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Mouse DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F7170

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

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Mouse DMD / Dystrophin (Competitive EIA) ELISA Kit - LS-F28303

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Dog DMD / Dystrophin (Custom ELISA) ELISA Kit - LS-F17673

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat DMD / Dystrophin (Custom ELISA) ELISA Kit - LS-F17674

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Chicken DMD / Dystrophin (Custom ELISA) ELISA Kit - LS-F17675

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Pig DMD / Dystrophin (Custom ELISA) ELISA Kit - LS-F17676

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse DMD / Dystrophin (Custom ELISA) ELISA Kit - LS-F17677

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F21102

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F22803

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F22231

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F26832

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Rat DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F35018

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F35020

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat DMD / Dystrophin (CLIA) ELISA Kit - LS-F37532

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human DMD / Dystrophin (CLIA) ELISA Kit - LS-F29911

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse DMD / Dystrophin (CLIA) ELISA Kit - LS-F30641

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F27410

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

25 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Guinea pig DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43404

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43406

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43407

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43408

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Sheep DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43409

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

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Rabbit DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F43411

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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