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DLG4 / PSD95

discs, large homolog 4 (Drosophila)

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

Gene Name: discs, large homolog 4 (Drosophila)
Family/Subfamily: MAGUK
Synonyms: DLG4, Disks large homolog 4, Presynaptic density protein 95, PSD95, SAP-90, Synapse-associated protein 90, PSD-95, SAP90, Tax interaction protein 15, Discs large homolog 4
Target Sequences: NM_001365 NP_001356.1 P78352

Publications (4)

1
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG. Scientific reports. 2016 6:24626. (ICC; Human) [Full Text Article] [PubMed:27109929] [PMC:PMC4842999]
2
Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang TL. Frontiers in aging neuroscience. 2016 July;8:175. [Full Text Article] [PubMed:27493629] [PMC:PMC4954850]
3
Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota. Jianfeng Liu, Tianhua Zhang, Yingying Wang, Chengqing Si, Xudong Wang, Rui-Tao Wang, Zhonghua Lv. Aging. 2020 February;12:3791-3806. [Full Text Article] [PubMed:32084011] [PMC:PMC7066900]
4
Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice. Qiu-Jun Wang, Yue-E Shen, Xin Wang, Shuang Fu, Xin Zhang, Yi-Na Zhang, Rui-Tao Wang. Aging. 2020 January;12:628-649. [Full Text Article] [PubMed:31907339] [PMC:PMC6977692]
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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
DLG4 / PSD95 (7)
No (7)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
81.9kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
DLG4 / PSD95 Protein - Purified recombinant protein DLG4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
85.2 kDa
20 µg/$1,107
DLG4 / PSD95 Protein - 12.5% SDS-PAGE of human DLG4 stained with Coomassie Blue
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Wheat Germ Extract
GST
111.8 kDa
10 µg/$479; 25 µg/$670
DLG4 / PSD95 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DLG4 / PSD95 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
85.2 kDa
20 µg/$215
DLG4 / PSD95 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
85.2 kDa
100 µg/$710
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
81.9 kDa
10 µg/$288; 50 µg/$436
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).