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DLG4 / PSD95

discs, large homolog 4 (Drosophila)

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.

Gene Name: discs, large homolog 4 (Drosophila)
Family/Subfamily: MAGUK
Synonyms: DLG4, Disks large homolog 4, Presynaptic density protein 95, PSD95, SAP-90, Synapse-associated protein 90, PSD-95, SAP90, Tax interaction protein 15, Discs large homolog 4
Target Sequences: NM_001365 NP_001356.1 P78352

Publications (4)

1
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG. Scientific reports. 2016 6:24626. (ICC; Human) [Full Text Article] [PubMed:27109929] [PMC:PMC4842999]
2
Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang TL. Frontiers in aging neuroscience. 2016 July;8:175. [Full Text Article] [PubMed:27493629] [PMC:PMC4954850]
3
Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota. Jianfeng Liu, Tianhua Zhang, Yingying Wang, Chengqing Si, Xudong Wang, Rui-Tao Wang, Zhonghua Lv. Aging. 2020 February;12:3791-3806. [Full Text Article] [PubMed:32084011] [PMC:PMC7066900]
4
Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice. Qiu-Jun Wang, Yue-E Shen, Xin Wang, Shuang Fu, Xin Zhang, Yi-Na Zhang, Rui-Tao Wang. Aging. 2020 January;12:628-649. [Full Text Article] [PubMed:31907339] [PMC:PMC6977692]
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Antibodies (77)
Primary (77)
DLG4 / PSD95 (77)
Human (69)
Mouse (51)
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rabbit (34)
mouse (42)
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monoclonal mc (41)
polyclonal pc (36)
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OTI12A5 (2)
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aa683-732 (4)
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aa253-302 (1)
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No (77)
DLG4 / PSD95 Antibody - Anti-DLG4 / PSD95 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
DLG4 / PSD95 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
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DLG4 / PSD95 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IF, IP, WB
APC Conjugated
100 µl/$1,017
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Unconjugated
25 µg/$312; 100 µg/$425
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (Biotin) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Biotin Conjugated
100 µg/$458
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (FITC) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
FITC Conjugated
100 µg/$456
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 390) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 390 Conjugated
100 µg/$463
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 488) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 488 Conjugated
100 µg/$462
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (Atto 594) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Atto 594 Conjugated
100 µg/$462
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (APC) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
APC Conjugated
100 µg/$461
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (RPE) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
RPE Conjugated
100 µg/$459
DLG4 / PSD95 Antibody - ICC of PSD95 in cultures of dissociated rat hippocampal neurons.  Fixation: Cold 4% paraformaldehyde/0.2% glutaraldehyde in 0.1M sodium phosphate buffer. Primary Antibody: Mouse Anti-PSD95 at 1:1000 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse IgG (green) at 1:50 for 30 minutes at RT. Experiment performed with the unconjugated form of the antibody. Other forms have not been tested.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (PerCP) (6G6) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
PerCP Conjugated
100 µg/$461
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DLG4 / PSD95 Mouse anti-Rat Monoclonal Antibody
Mouse, Bovine, Rat, Human
ICC, IF, WB
Unconjugated
25 µg/$488; 100 µg/$672
DLG4 / PSD95 Antibody - Anti-PSD95 antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DLG4 / PSD95 Rabbit anti-Human Polyclonal (aa683-732) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
DLG4 / PSD95 Antibody - DLG4 antibody (1 ug/ml) staining of Mouse Brain lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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DLG4 / PSD95 Goat anti-Human Polyclonal (aa667-679) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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DLG4 / PSD95 Mouse anti-Mouse Monoclonal (6G6-1C9) Antibody
Mouse, Bovine, Rat
ICC, WB
Unconjugated
100 µg/$531
DLG4 / PSD95 Antibody - Western blot of PSD-95 antibody
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DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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DLG4 / PSD95 Mouse anti-Human Monoclonal Antibody
Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$804
DLG4 / PSD95 Antibody - RAT DLG4 Antibody (Ascites) immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the RAT DLG4 Antibody (Ascites) for immunohistochemistry.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (aa677-706) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$393
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DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$414
DLG4 / PSD95 Antibody - Detection of PSD95 in rat neocortex
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DLG4 / PSD95 Mouse anti-Mouse Monoclonal (7E3-1B8) Antibody
Mouse, Bovine, Rat
ICC, IF, WB
Unconjugated
100 µg/$531
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DLG4 / PSD95 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
DLG4 / PSD95 Antibody - ICC localization of Psd95 in rat neocortex.
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DLG4 / PSD95 Mouse anti-Rat Monoclonal (7E3) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, IHC, WB
Unconjugated
25 µg/$312; 100 µg/$425
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DLG4 / PSD95 Mouse anti-Human Monoclonal Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$854
DLG4 / PSD95 Antibody - DLG4 / PSD95 antibody. IHC(P): Human Intestinal Cancer Tissue.
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DLG4 / PSD95 Rabbit anti-Human Polyclonal (aa492-507) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
DLG4 / PSD95 Antibody - PSD95 antibody IHC-paraffin. IHC(P): Human Glioma Tissue.
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DLG4 / PSD95 Rabbit anti-Human Polyclonal (aa581-724) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).