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DLG3 / SAP102 is a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
Gene Name: | discs, large homolog 3 (Drosophila) |
Family/Subfamily: | MAGUK |
Synonyms: | DLG3, Disks large homolog 3, KIAA1232, MRX, MRX90, NEDLG, Neuroendocrine-DLG, SAP102, Synapse-associated protein 102, NE-Dlg, Presynaptic protein sap102, SAP-102, XLMR |
Target Sequences: | NM_021120 NP_066943.2 Q92796 |
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