DISC1

Disrupted in Schizophrenia 1

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

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Products

Antibodies (74)

Proteins (16)

Type

Over-Expression Lysate (12)

Primary (74)

Recombinant (4)

Target

DISC1 (90)

Reactivity

Human (51)

Mouse (43)

Rat (30)

Chimpanzee (1)

Application

IHC (35)

IHC-P (16)

WB (69)

Flo (6)

ELISA (19)

ICC (1)

IF (4)

IP (1)

Peptide-ELISA (1)

Host

rabbit (68)

mouse (3)

rabbit-new zealand white (2)

sheep (1)

Product Group

IHCPlus (5)

Isotype

IgG (24)

IgG1 (1)

IgM (2)

Clonality

monoclonal mc (3)

polyclonal pc (71)

Clone

1D4B (1)

Format

APC (3)

APC Conjugated (4)

Biotin Conjugated (8)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

DY488 Conjugated (2)

DY550 Conjugated (2)

DY650 Conjugated (2)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (5)

Unconjugated (33)

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Epitope

aa701-728 (9)

aa102-261 (8)

aa151-330 (8)

aa151-340 (8)

aa400-500 (5)

C-Terminus (4)

aa700-800 (3)

N-Terminus (2)

aa101-260 (2)

23-85 (1)

aa461-477 (1)

aa74-91 (1)

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Publications

No (89)

Yes (1)

Tag

His-T7 (3)

Myc-DDK (Flag) (13)

Species

Human (8)

Mouse (1)

Rat (1)

Source

293T Cells (6)

E. coli (3)

HEK 293 Cells (7)

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IHC-plus™ DISC1 Antibody (C-Terminus) LS-B2805

(5.0) Rating

(2) Publication(s)

Antibody:

DISC1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ DISC1 Antibody (C-Terminus) LS-B2630

(4.0) Rating

Antibody:

DISC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ DISC1 Antibody (aa700-800) LS-B2673

(4.0) Rating

Antibody:

DISC1 Rabbit anti-Mouse Polyclonal (aa700-800) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$460

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DISC1 Antibody (Biotin) LS-C179968

Antibody:

DISC1 Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

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DISC1 Antibody (DY488) LS-C179969

Antibody:

DISC1 Rabbit anti-Mouse Polyclonal (DY488) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, WB

Format:

DY488 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY488

• Unconjugated
• Biotin
• DY488

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IHC-plus™ DISC1 Antibody (C-Terminus) LS-B2631

(4.0) Rating

Antibody:

DISC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

DISC1 Antibody (N-Terminus) LS-C46989

Antibody:

DISC1 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$379

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IHC-plus™ DISC1 Antibody (aa400-500) LS-B6875

(4.0) Rating

Antibody:

DISC1 Rabbit anti-Rat Polyclonal (aa400-500) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$460

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DISC1 Antibody LS-C34730

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

Select

DISC1 Antibody LS-C754750

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

DISC1 Antibody (aa701-728) LS-C167423

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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DISC1 Antibody (aa701-728) LS-C320848

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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DISC1 Antibody (aa701-728, HRP) LS-C540409

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

200 µl/$952

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DISC1 Antibody (aa701-728, Biotin) LS-C520221

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

DISC1 Antibody (aa701-728, FITC) LS-C234611

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

DISC1 Antibody (aa701-728, APC) LS-C234610

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

DISC1 Antibody (aa701-728, PE) LS-C234613

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa701-728) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

Select

DISC1 Antibody LS-C502071

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

DISC1 Antibody (aa461-477) LS-C344096

Antibody:

DISC1 Rabbit anti-Human Polyclonal (aa461-477) Antibody

Reactivity:

Mouse, Rat, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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DISC1 Antibody LS-C803767

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

DISC1 Antibody LS-C332281

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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DISC1 Antibody (aa101-260, clone 1D4B) LS-C189800

Antibody:

DISC1 Mouse anti-Human Monoclonal (aa101-260) (1D4B) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$884

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DISC1 Antibody LS-C482384

Antibody:

DISC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386

Select

DISC1 Antibody LS-C829356

Antibody:

DISC1 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

Select

DISC1 Antibody LS-C829357

Antibody:

DISC1 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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