DIO3

deiodinase, iodothyronine, type III

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

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Proteins (6)

Type

Recombinant (6)

Target

DIO3 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-MBP (1)

Species

Human (2)

Mouse (1)

Rat (3)

Source

E. coli (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human DIO3 Protein (Recombinant GST, N-terminus) (aa43-143) - LS-G58337

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat DIO3 Protein (Recombinant His) (aa37-278) - LS-G23283

Source:

Yeast

Tag:

His

Molecular Weight:

29.4 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Rat DIO3 Protein (Recombinant His) (aa37-278) - LS-G21491

Source:

E. coli

Tag:

His

Molecular Weight:

31.5 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human DIO3 Protein (Recombinant GST) (Full Length) - LS-G28206

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.47 kDa

Price:

2 µg/$439

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Rat DIO3 Protein (Recombinant His-MBP) (aa11-277) - LS-G15721

Source:

E. coli

Tag:

His-MBP

Molecular Weight:

60.4 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse DIO3 Protein (Recombinant His, N-Terminal) (Arg11-Arg277) - LS-G133034

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

77.0kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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