DIO3

deiodinase, iodothyronine, type III

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

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Products

ELISA Kits (10)

Type

Custom (5)

Sandwich (5)

Target

DIO3 (10)

Reactivity

Human (2)

Mouse (2)

Rat (3)

Chicken (1)

Pig (1)

Format

96-Well Strip Plate (10)

Publications

No (10)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (4)

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Rat DIO3 (Sandwich ELISA) ELISA Kit - LS-F33468

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse DIO3 (Sandwich ELISA) ELISA Kit - LS-F7780

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$748

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Rat DIO3 (Sandwich ELISA) ELISA Kit - LS-F8100

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$783

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Rat DIO3 (Sandwich ELISA) ELISA Kit - LS-F13278

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse DIO3 (Custom ELISA) ELISA Kit - LS-F16510

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Pig DIO3 (Custom ELISA) ELISA Kit - LS-F16511

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human DIO3 (Custom ELISA) ELISA Kit - LS-F16512

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine DIO3 (Custom ELISA) ELISA Kit - LS-F16513

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Chicken DIO3 (Custom ELISA) ELISA Kit - LS-F16514

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human DIO3 (Sandwich ELISA) ELISA Kit - LS-F33467

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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