DIO3

deiodinase, iodothyronine, type III

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

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Products

Antibodies (36)

Type

Primary (36)

Target

DIO3 (36)

Reactivity

Human (17)

Mouse (8)

Rat (21)

Hamster (1)

Monkey (1)

Rabbit (1)

Application

IHC (8)

IHC-P (1)

WB (32)

ELISA (15)

ICC (2)

IF (1)

Peptide-ELISA (2)

Host

rabbit (36)

Isotype

IgG (18)

Clonality

polyclonal pc (36)

Format

APC (1)

APC Conjugated (2)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (12)

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Epitope

aa11-277 (11)

Internal (7)

aa250-278 (7)

aa37-278 (4)

aa17-66 (1)

Publications

No (36)

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DIO3 Antibody (Internal) LS-C383145

Antibody:

DIO3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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DIO3 Antibody LS-C809824

Antibody:

DIO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DIO3 Antibody (aa250-278) LS-C320845

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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DIO3 Antibody (aa250-278, HRP) LS-C540410

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

200 µl/$952

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DIO3 Antibody (aa250-278, Biotin) LS-C520220

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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DIO3 Antibody (aa250-278, FITC) LS-C256119

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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DIO3 Antibody (aa250-278, APC) LS-C256118

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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DIO3 Antibody (aa250-278, PE) LS-C256120

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

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DIO3 Antibody (aa250-278) LS-C167418

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa250-278) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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DIO3 Antibody LS-C677671

Antibody:

DIO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (HRP) LS-C677672

Antibody:

DIO3 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (Biotin) LS-C682172

Antibody:

DIO3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (FITC) LS-C677673

Antibody:

DIO3 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

DIO3 Antibody LS-C409084

Antibody:

DIO3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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DIO3 Antibody (aa11-277, Biotin) LS-C424031

Antibody:

DIO3 Rabbit anti-Mouse Polyclonal (aa11-277) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$321

Select

DIO3 Antibody (aa11-277, FITC) LS-C424033

Antibody:

DIO3 Rabbit anti-Mouse Polyclonal (aa11-277) (FITC) Antibody

Reactivity:

Mouse

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$331

Select

DIO3 Antibody (aa17-66) LS-C199830

Antibody:

DIO3 Rabbit anti-Human Polyclonal (aa17-66) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

DIO3 Antibody (aa37-278) LS-C371085

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (aa37-278) Antibody

Reactivity:

Rat

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (aa37-278, HRP) LS-C371096

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (aa37-278) (HRP) Antibody

Reactivity:

Rat

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (aa37-278, Biotin) LS-C371089

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (aa37-278) (Biotin) Antibody

Reactivity:

Rat

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

DIO3 Antibody (aa37-278, FITC) LS-C371092

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (aa37-278) (FITC) Antibody

Reactivity:

Rat

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

DIO3 Antibody (aa11-277) LS-C314988

Antibody:

DIO3 Rabbit anti-Mouse Polyclonal (aa11-277) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571

Select

DIO3 Antibody (Internal) LS-C352116

Antibody:

DIO3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

DIO3 Antibody (Internal) LS-C142484

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (Internal) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

DIO3 Antibody (aa11-277) LS-C293665

Antibody:

DIO3 Rabbit anti-Rat Polyclonal (aa11-277) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331

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