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DICER1 / Dicer
dicer 1, ribonuclease type III
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
| Gene Name: | dicer 1, ribonuclease type III |
| Synonyms: | DICER1, DCR1, Dicer, Dicer 1, ribonuclease type III, Endoribonuclease Dicer, HERNA, Helicase-moi, MNG1, Helicase with RNase motif, Dicer1, Dcr-1 homolog, Helicase MOI, K12H4.8-LIKE, KIAA0928 |
| Target Sequences: | NM_030621 NP_085124.2 Q9UPY3 |
Publications (1)
1
Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas. Raisa A Reyes-Castro, Shin-Yu Chen, Jacob Seemann, Samrat T Kundu, Don L Gibbons, Swathi Arur. Science advances. 2023 July;9:eadf6210. [Full Text Article]
[PubMed:37494452]
[PMC:PMC10577638]
Related Antibodies: LS-C338518.
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(46)
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DICER1 / Dicer
(46)
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(45)
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(34)
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(45)
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(1)
DICER1 / Dicer Rabbit anti-Human Polyclonal (aa1423-1440) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
DICER1 / Dicer Mouse anti-Human Monoclonal (aa1666-1922) (OTI1D9) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
DICER1 / Dicer Mouse anti-Human Monoclonal (aa879-908) Antibody
Human
WB
Unconjugated
0.1 ml/$393
DICER1 / Dicer Mouse anti-Human Monoclonal (aa1666-1922) (OTI1G8) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
DICER1 / Dicer Mouse anti-Human Monoclonal (aa1666-1922) (Carrier-free) (OTI1G8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DICER1 / Dicer Rabbit anti-Human Polyclonal (aa1100-1300) Antibody
Mouse, Human
ICC, IHC, IHC-P
Unconjugated
0.05 ml/$386
DICER1 / Dicer Rabbit anti-Human Polyclonal (aa600-650) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
DICER1 / Dicer Rabbit anti-Human Polyclonal (aa1175-1225) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
DICER1 / Dicer Mouse anti-Mouse Monoclonal (S167-7) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$537
DICER1 / Dicer Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
DICER1 / Dicer Rabbit anti-Human Polyclonal (aa1-195) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
DICER1 / Dicer Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
DICER1 / Dicer Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
100 µg/$442
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (Biotin) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Biotin Conjugated
100 µg/$475
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (FITC) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
FITC Conjugated
100 µg/$472
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (RPE) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
RPE Conjugated
100 µg/$477
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (PerCP) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
PerCP Conjugated
100 µg/$478
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (Atto 390) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Atto 390 Conjugated
100 µg/$479
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (Atto 488) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Atto 488 Conjugated
100 µg/$479
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (Atto 594) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Atto 594 Conjugated
100 µg/$479
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (APC) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
APC Conjugated
100 µg/$478
DICER1 / Dicer Mouse anti-Mouse Monoclonal (aa1638-1899) (S167-7) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
100 µg/$665
DICER1 / Dicer Rabbit-New Zealand White anti-Mouse Polyclonal (aa1200-1250) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
DICER1 / Dicer Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$332
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product results
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