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Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics.
Gene Name: | diaphanous-related formin 3 |
Synonyms: | DIAPH3, AUNA1, DRF3, Diap3, Diaphanous-related formin-3, DIA2, MDia2, NSDAN, Protein diaphanous homolog 3 |
Target Sequences: | NM_030932 NP_112194.2 Q9NSV4 |
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