DGCR8

DGCR8 microprocessor complex subunit

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

DGCR8 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DGCR8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82563

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.9 kDa

Price:

20 µg/$215

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Human DGCR8 Protein (Recombinant GST, N-terminus) (aa675-771) - LS-G62585

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DGCR8 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68587

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.9 kDa

Price:

20 µg/$1,107

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DGCR8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101818

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.9 kDa

Price:

100 µg/$710

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Human DGCR8 Protein (Recombinant GST) (Full Length) - LS-G33982

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

112.4 kDa

Price:

10 µg/$479; 25 µg/$670

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