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DERL1 / Derlin 1
derlin 1
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
| Gene Name: | derlin 1 |
| Synonyms: | DERL1, DER1, Der1-like protein 1, Derlin-1, DERtrin-1, PRO2577, DER-1, Derlin 1 |
| Target Sequences: | NM_024295 NP_077271.1 Q9BUN8 |
Publications (1)
1
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. Huttunen HJ, Gunette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. The Journal of biological chemistry. 2007 282:28285-95.
[PubMed:17684015]
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Products
Antibodies
(31)
Type
Primary
(31)
Target
DERL1 / Derlin 1
(31)
Reactivity
Human
(31)
Mouse
(12)
Application
IHC
(10)
IHC-P
(7)
WB
(30)
Flo
(1)
ELISA
(15)
ICC
(2)
IF
(1)
IP
(2)
Host
rabbit
(25)
mouse
(6)
Product Group
IHCPlus
(2)
Isotype
IgG
(10)
IgG1,k
(6)
Clonality
monoclonal mc
(6)
polyclonal pc
(25)
Format
APC Conjugated
(2)
Biotin Conjugated
(4)
DY488 Conjugated
(1)
DY550 Conjugated
(1)
DY650 Conjugated
(1)
FITC Conjugated
(3)
HRP Conjugated
(3)
PE Conjugated
(2)
Unconjugated
(14)
Epitope
C-Terminus
(11)
aa224-251
(7)
N-Terminus
(1)
aa134-233
(1)
aa200-251
(1)
aa201-251
(1)
Publications
No
(31)
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa200-251) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (aa134-233) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
DERL1 / Derlin 1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa201-251) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µg/$430
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$649
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$379
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal (aa224-251) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
DERL1 / Derlin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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of 31
product results
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