Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
Gene Name: | DENN/MADD domain containing 1B |
Synonyms: | DENND1B, C1ORF18, C1orf218, Connecdenn 2, DENN/MADD domain containing 1B, Protein FAM31B, FAM31B, RP11-53I24.2 |
Target Sequences: | NM_001142795 NP_659414.2 Q6P3S1 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.