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DENND1A
DENN/MADD domain containing 1A
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles.
| Gene Name: | DENN/MADD domain containing 1A |
| Synonyms: | DENND1A, Connecdenn 1, Connecdenn, DENN/MADD domain containing 1A, FAM31A, KIAA1608, RP11-230L22.3, Protein FAM31A |
| Target Sequences: | AB046828 BAB13434.2 Q8TEH3 |
Publications (2)
1
Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-1010<sup> Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, 60637, USA. aalhendy@BSD.Uchicago.edu. Rishi Man Chugh # , Hang-Soo Park #, Abdeljabar El Andaloussi #, Amro Elsharoud, Sahar Esfandyari, Mara Ulin, Lale Bakir, Alshimaa Aboalsoud , Mohamed Ali , Dalia Ashour, Prosper Igboeli, Nahed Ismail, Jan McAllister, Ayman Al-Hendy. Stem cell research & therapy. 2021 Jul;12:388. [Full Text Article]
[PubMed:34233746]
[PMC:PMC8261924]
Related Antibodies: LS-C167356.
2
Mesenchymal Stem Cell-Conditioned Media Regulate Steroidogenesis and Inhibit Androgen Secretion in a PCOS Cell Model via BMP-2. Rishi Man Chugh , Hang-Soo Park, Sahar Esfandyari, Amro Elsharoud, Mara Ulin, Ayman Al-Hendy. International journal of molecular sciences. 2021 Aug;22:9184. [Full Text Article]
[PubMed:34502090]
[PMC:PMC8431467]
Related Antibodies: LS-C167356.
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Proteins
(4)
Type
Over-Expression Lysate
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Recombinant
(2)
Target
DENND1A
(4)
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No
(4)
Tag
GST
(1)
His-SUMO
(1)
Myc-DDK (Flag)
(2)
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Human
(3)
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293T Cells
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(1)
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Wheat Germ Extract
GST
89.8 kDa
2 µg/$439
293T Cells
Myc-DDK (Flag)
63.2 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
63.2 kDa
100 µg/$494
E. coli
His-SUMO
79.35 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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