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Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
Gene Name: | fatty acid desaturase 2 |
Synonyms: | FADS2, D6D, Delta-6 fatty acid desaturase, Delta-6-desaturase, FADSD6, LLCDL2, SLL0262, TU13, Delta(6) desaturase, Delta(6) fatty acid desaturase, Delta-6 desaturase, DES6, Fatty acid desaturase 2 |
Target Sequences: | NM_004265 NP_004256.1 O95864 |
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