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Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey. Mutation of this gene is associated with impaired sperm function.
Gene Name: | defensin, beta 126 |
Synonyms: | DEFB126, Beta defensin 26, Defensin, beta 126, DEFB26, ESP13.2, HBD-26, BA530N10.1, Beta-defensin 126, Beta-defensin 26, C20orf8, DEFB-26 |
Target Sequences: | NM_030931 NP_112193.1 Q9BYW3 |
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