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Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.
Gene Name: | defensin, beta 104A |
Synonyms: | DEFB104A, Beta-defensin 4, BD-4, Beta-defensin 104, Defensin, beta 104, Defensin, beta 104A, Defensin, beta 4, DEFB4, HBD-4, DEFB-4, DEFB104 |
Target Sequences: | Q8WTQ1 Q8WTQ1 |
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