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Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).
Gene Name: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
Synonyms: | DDX60, DEAD box protein 60 |
Target Sequences: | NM_017631 NP_060101.3 Q8IY21 |
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