DDX58 / RIG-1 / RIG-I

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

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Products

Antibodies (60)

Proteins (6)

Type

Over-Expression Lysate (1)

Primary (60)

Recombinant (5)

Target

DDX58 / RIG-1 / RIG-I (66)

Reactivity

Human (52)

Mouse (21)

Rat (8)

Chimpanzee (3)

Horse (3)

Monkey (1)

Application

IHC (23)

IHC-P (9)

WB (55)

Flo (2)

ELISA (11)

IF (6)

IP (4)

Peptide-ELISA (2)

Host

rabbit (47)

mouse (11)

goat (2)

Product Group

IHCPlus (4)

Isotype

IgG (21)

IgG1 (4)

IgG1,k (1)

IgG2a (2)

IgG2b (2)

IgM (1)

Clonality

monoclonal mc (10)

polyclonal pc (50)

Clone

4G1B6 (1)

ABM4H29 (1)

Alme-1 (2)

OTI6C1 (2)

OTI7D5 (2)

OTI8D2 (2)

Format

APC (2)

APC Conjugated (2)

Biotin Conjugated (6)

Carrier-free (3)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (3)

Unconjugated (35)

Epitope

aa1-211 (8)

aa550-776 (8)

aa827-876 (4)

aa201-713 (2)

C-Terminus (1)

aa1-220 (1)

aa200-250 (1)

aa585-614 (1)

aa894-925 (1)

Publications

No (63)

Yes (3)

Tag

GST (1)

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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IHC-plus™ DDX58 / RIG-1 / RIG-I Antibody (C-Terminus) LS-B3768

(5.0) Rating

(1) Publication(s)

Antibody:

DDX58 / RIG-1 / RIG-I Goat anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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DDX58 / RIG-1 / RIG-I Antibody LS-C331000

(4.0) Rating

(1) Publication(s)

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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DDX58 / RIG-1 / RIG-I Antibody (aa201-713, clone Alme-1) LS-C344928

(4.0) Rating

(1) Publication(s)

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (aa201-713) (Alme-1) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µg/$505

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DDX58 / RIG-1 / RIG-I Antibody (aa201-713, clone Alme-1, Biotin) LS-C344741

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (aa201-713) (Biotin) (Alme-1) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Biotin Conjugated

Price:

100 µg/$526

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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IHC-plus™ DDX58 / RIG-1 / RIG-I Antibody (aa200-250) LS-B8006

(4.0) Rating

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal (aa200-250) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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DDX58 / RIG-1 / RIG-I Antibody (clone OTI6C1) LS-C174703

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (OTI6C1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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DDX58 / RIG-1 / RIG-I Antibody (clone OTI6C1, Carrier-free) LS-C788068

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (Carrier-free) (OTI6C1) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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DDX58 / RIG-1 / RIG-I Antibody (aa1-211) LS-C296231

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Mouse Polyclonal (aa1-211) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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Mouse DDX58 / RIG-1 / RIG-I Protein (Recombinant His, N-Terminal) (Met1-Gln211) - LS-G13962

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

28.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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DDX58 / RIG-1 / RIG-I Antibody (clone OTI8D2) LS-C174735

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (OTI8D2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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DDX58 / RIG-1 / RIG-I Antibody (clone OTI8D2, Carrier-free) LS-C788115

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (Carrier-free) (OTI8D2) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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DDX58 / RIG-1 / RIG-I Antibody (Biotin) LS-C317743

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant His, N-Terminal) (Asp550-Phe776) - LS-G13959

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant GST) (Full Length) - LS-G32902

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

133 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71497

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.4 kDa

Price:

20 µg/$1,107

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Human DDX58 / RIG-1 / RIG-I Protein (Recombinant His) (aa1-430) - LS-G20665

Source:

E. coli

Tag:

His

Molecular Weight:

53.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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IHC-plus™ DDX58 / RIG-1 / RIG-I Antibody (aa1-220, clone ABM4H29) LS-B14053

(4.0) Rating

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (aa1-220) (ABM4H29) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

DDX58 / RIG-1 / RIG-I Antibody (aa894-925) LS-C97877

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal (aa894-925) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

DDX58 / RIG-1 / RIG-I Antibody LS-C19644

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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DDX58 / RIG-1 / RIG-I Antibody (HRP) LS-C549285

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$973

Select

IHC-plus™ DDX58 / RIG-1 / RIG-I Antibody LS-B3834

(4.0) Rating

Antibody:

DDX58 / RIG-1 / RIG-I Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

DDX58 / RIG-1 / RIG-I Antibody LS-C665048

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

DDX58 / RIG-1 / RIG-I Antibody LS-C766025

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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DDX58 / RIG-1 / RIG-I Antibody LS-C665046

Antibody:

DDX58 / RIG-1 / RIG-I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

DDX58 / RIG-1 / RIG-I Antibody (clone 4G1B6) LS-C669519

Antibody:

DDX58 / RIG-1 / RIG-I Mouse anti-Human Monoclonal (4G1B6) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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