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ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
Gene Name: | DEAD (Asp-Glu-Ala-Asp) box helicase 42 |
Family/Subfamily: | DEAD box protein |
Synonyms: | DDX42, DEAD box protein 42, RNAHP, RNA helicase-like protein, SF3b125, RNA helicase-related protein, SF3b125 DEAD-box protein, RHELP, SF3b DEAD box protein |
Target Sequences: | NM_007372 NP_031398.2 Q86XP3 |
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