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DDR2

discoidin domain receptor tyrosine kinase 2

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Gene Name: discoidin domain receptor tyrosine kinase 2
Family/Subfamily: Protein Kinase , DDR/TKT
Synonyms: DDR2, CD167b antigen, Discoidin domain receptor 2, Hydroxyaryl-protein kinase, MIG20a, Tyrosine-protein kinase TYRO10, NTRKR3, TYRO10, Tyrosylprotein kinase
Target Sequences: NM_006182 NP_006173.2 Q16832

Publications (6)

1
Region and cell-type resolved quantitative proteomic map of the human heart. Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M. Nature communications. 2017 November;8:1469. (Human) [Full Text Article] [PubMed:29133944] [PMC:PMC5684139] Related Antibodies: LS-C99151.
2
Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Genes & development. 2018 February;32:244-257. [Full Text Article] [PubMed:29483153] [PMC:PMC5859966] Related Antibodies: LS-C164363.
3
Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display. Travis J Antes, Ryan C Middleton, Kristin M Luther, Takeshi Ijichi, Kiel A Peck, Weixin Jane Liu, Jackie Valle, Antonio K Echavez, Eduardo Marbán. Journal of nanobiotechnology. 2018 Aug;16:61. [Full Text Article] [PubMed:30165851] [PMC:PMC6116387] Related Antibodies: LS-C255960.
4
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling. Tariq Hamid, Yuanyuan Xu, Mohamed Ameen Ismahil, Gregg Rokosh, Miki Jinno, Guihua Zhou, Qiongxin Wang, Sumanth D Prabhu. JACC. Basic to translational science. 2022 May;7:465-483. [Full Text Article] [PubMed:35663630] [PMC:PMC9156441] Related Antibodies: LS-C255961.
5
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Fatma F Mohamed, Chunxi Ge, Randy T Cowling, Daniel Lucas, Shawn A Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T Franceschi. Bone research. 2022 February;10:11. [Full Text Article] [PubMed:35140200] [PMC:PMC8828874] Related Antibodies: LS-B15752.
6
Synthetic peptides activating discoidin domain receptor 2 and collagen-binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Chunxi Ge, Yiming Li, Fashuai Wu, Peter Ma, Renny T Franceschi. Acta biomaterialia. 2023 August;166:109-118. [Full Text Article] [PubMed:37245640] [PMC:PMC10643765] Related Antibodies: LS-B15752.
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DDR2 ELISA Kit
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96-Well Strip Plate
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
DDR2 ELISA Kit
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96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$764
DDR2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DDR2 ELISA Kit
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96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
DDR2 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$823
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).