DDIT3 / CHOP

DNA-damage-inducible transcript 3

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

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Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

DDIT3 / CHOP (11)

Publications

No (11)

Tag

GST (1)

GST, N-terminus (2)

GST, N-terminus + His, C-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (4)

Species

Human (8)

Mouse (1)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human DDIT3 / CHOP Protein (Recombinant His) - LS-G3419

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human DDIT3 / CHOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89231

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.1 kDa

Price:

20 µg/$150

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Human DDIT3 / CHOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89232

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19 kDa

Price:

20 µg/$150

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Human DDIT3 / CHOP Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G58313

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DDIT3 / CHOP Protein (Recombinant GST, N-terminus) (aa94-155) - LS-G58315

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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DDIT3 / CHOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130765

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.1 kDa

Price:

100 µg/$494

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DDIT3 / CHOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116883

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19 kDa

Price:

100 µg/$494

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Human DDIT3 / CHOP Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144828

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

45 kDa

Price:

50 µg/$419

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Mouse DDIT3 / CHOP Protein (Recombinant His-GST) (aa1-168) - LS-G25975

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human DDIT3 / CHOP Protein (Recombinant GST) (Full Length) - LS-G28176

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DDIT3 / CHOP Protein (Recombinant His) (aa1-169) - LS-G16004

Source:

E. coli

Tag:

His

Molecular Weight:

20.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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