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Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Gene Name: | DCN1, defective in cullin neddylation 1, domain containing 2 |
Synonyms: | DCUN1D2, DCN1-like protein 2, DCUN1L2, C13orf17 |
Target Sequences: | NM_001014283 NP_001014305.1 Q6PH85 |
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