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DCTPP1 / XTP3TPA

dCTP pyrophosphatase 1

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.

Gene Name: dCTP pyrophosphatase 1
Synonyms: DCTPP1, DCTPase 1, CDA03, DCTP pyrophosphatase 1, RS21C6, XTP3TPA, XTP3-transactivated protein A, Deoxycytidine-triphosphatase 1
Target Sequences: NM_024096 NP_077001.1 Q9H773

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
DCTPP1 / XTP3TPA (5)
No (5)
GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
DCTPP1 / XTP3TPA Protein - Purified recombinant protein DCTPP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
18.5 kDa
20 µg/$1,107
DCTPP1 / XTP3TPA Protein - 12.5% SDS-PAGE of human XTP3TPA stained with Coomassie Blue
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Wheat Germ Extract
GST
45.1 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
18.5 kDa
20 µg/$150
DCTPP1 / XTP3TPA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
18.5 kDa
100 µg/$494
DCTPP1 / XTP3TPA Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).