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DCTD / dCMP Deaminase catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | dCMP deaminase |
Synonyms: | DCTD, DCMP deaminase, Deoxycytidylate deaminase |
Target Sequences: | NM_001921 NP_001912.2 P32321 |
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