DCLK / DCLK1

doublecortin-like kinase 1

DCLK / DCLK1 is a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

DCLK / DCLK1 (8)

Publications

No (8)

Tag

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (7)

Source

293T Cells (1)

Baculovirus (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human DCLK / DCLK1 Protein (Recombinant) (Met1-Val705) - LS-G98567

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78.5 kDa

Price:

50 µg/$625

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Human DCLK / DCLK1 Protein (Recombinant GST, N-terminus) (aa640-729) - LS-G61029

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DCLK / DCLK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67404

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$1,107

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Human DCLK / DCLK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67406

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$1,107

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Human DCLK / DCLK1 Protein (Recombinant His-T7) (aa390-647) - LS-G25600

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human DCLK / DCLK1 Protein (Recombinant His-GST) (Met1-Val705) - LS-G97372

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

106 kDa

Price:

50 µg/$707

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Human DCLK / DCLK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79769

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

20 µg/$215

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DCLK / DCLK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116446

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.9 kDa

Price:

100 µg/$710

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