CYP3A4 / Cytochrome P450 3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4 / Cytochrome P450 3A4 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CYP3A4 / Cytochrome P450 3A4 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CYP3A4 / Cytochrome P450 3A4 Protein (Recombinant GST) (Full Length) - LS-G28135

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.7 kDa

Price:

2 µg/$439

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Human CYP3A4 / Cytochrome P450 3A4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65357

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$1,107

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Human CYP3A4 / Cytochrome P450 3A4 Protein (Recombinant GST, N-terminus) (aa404-503) - LS-G58283

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CYP3A4 / Cytochrome P450 3A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75414

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

20 µg/$150

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CYP3A4 / Cytochrome P450 3A4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112437

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.2 kDa

Price:

100 µg/$494

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Human CYP3A4 / Cytochrome P450 3A4 Protein (Recombinant His-T7) (aa344-497) - LS-G25250

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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