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CYP2E1

cytochrome P450, family 2, subfamily E, polypeptide 1

CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene Name: cytochrome P450, family 2, subfamily E, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP2E1, 4-nitrophenol 2-hydroxylase, CPE1, Cytochrome p450 IIe1, Cytochrome P450-J, p450C2E, p450-J, CYP2E, CYPIIE1, Cytochrome P450 2E1
Target Sequences: NM_000773 NP_000764.1 P05181

Publications (3)

1
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju. eLife. 2021 June;10: [Full Text Article] [PubMed:34110284] [PMC:PMC8233036] Related Antibodies: LS-C6332.
2
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Xiao-Wei Zhang, Ji-Chao Zhou, Dian Peng, Fang Hua, Ke Li, Jiao-Jiao Yu, Xiao-Xi Lv, Bing Cui, Shan-Shan Liu, Jin-Mei Yu, Feng Wang, Cai-Cai Jin, Zhao-Na Yang, Chen-Xi Zhao, Xue-Ying Hou, Bo Huang, Zhuo-Wei Hu. Autophagy. 2020 May;;16:782-796. [Full Text Article] [PubMed:31286822] [PMC:PMC7144866]
3
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, van Es JH, Huch M, Li VS, Jos[Character e9] A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H. Cell. 2012 Dec;151:1595-607. [Full Text Article] [PubMed:23260145] Related Antibodies: LS-C6332.

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ELISA Kits (23)
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CYP2E1 (23)
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CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$782
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CYP2E1 ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
CYP2E1 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
CYP2E1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CYP2E1 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
CYP2E1 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
CYP2E1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYP2E1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
43.75 - 2800 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$897
CYP2E1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
6.24 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,207; 1000 Wells/$1,787
CYP2E1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
6.24 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
500 Wells/$1,101; 1000 Wells/$1,612
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,018
CYP2E1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CYP2E1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CYP2E1 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CYP2E1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CYP2E1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).