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CYP1A1

cytochrome P450, family 1, subfamily A, polypeptide 1

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

Gene Name: cytochrome P450, family 1, subfamily A, polypeptide 1
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP1A1, AHH, Aryl hydrocarbon hydroxylase, Cytochrome P450-C, CP11, CYPIA1, Cytochrome P450 form 6, Cytochrome p450 ia1, Cytochrome P450 1A1, Cytochrome P450-P1, p1-450, p450-C, p450DX, CYP1
Target Sequences: NM_000499 NP_000490.1 P04798

Publications (1)

1
Prognostic value of using glucosylceramide synthase and cytochrome P450 family 1 subfamily A1 expression levels for patients with triple-negative breast cancer following neoadjuvant chemotherapy. Jiannan Liu, Shuhua Wang, Congcong Wang, Xiangshuo Kong, Ping Sun. Experimental and therapeutic medicine. 2021 March;21:247. [Full Text Article] [PubMed:33603855] [PMC:PMC7851625] Related Antibodies: LS-C99804.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
CYP1A1 (8)
No (8)
GST (1)
His-GST (1)
His-GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (4)
Mouse (1)
Rat (2)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
CYP1A1 Protein - Recombinant Cytochrome P450 1A1 By SDS-PAGE
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E. coli
His-GST
61.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CYP1A1 Protein - Purified recombinant protein CYP1A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
58 kDa
20 µg/$1,107
CYP1A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
58 kDa
100 µg/$494
CYP1A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
58 kDa
20 µg/$150
CYP1A1 Protein - 12.5% SDS-PAGE of human CYP1A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.06 kDa
2 µg/$439
CYP1A1 Protein
Select
E. coli
His-T7
31.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CYP1A1 Protein - Recombinant Cytochrome P450 1A1 By SDS-PAGE
Select
E. coli
His-T7
31.3 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
CYP1A1 Protein - Active Cytochrome P450 1A1 (CYP1A1) by WB
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E. coli
His-GST, N-terminus
62kDa
10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).