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CYP19 / Aromatase
cytochrome P450, family 19, subfamily A, polypeptide 1
CYP19 / Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants.
| Gene Name: | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP19A1, ARO1, CYAR, CPV1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, CYP19, Estrogen synthase, Estrogen synthetase, P-450AROM, ARO, Aromatase |
| Target Sequences: | NM_031226 NP_000094.2 P11511 |
Publications (8)
1
Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle. Bogan RL, Murphy MJ, Stouffer RL, Hennebold JD. Molecular endocrinology (Baltimore, Md.). 2008 22:1260-73.
[PubMed:18258683]
[PMC:PMC2366192]
2
Dynamic changes in gene expression that occur during the period of spontaneous functional regression in the rhesus macaque corpus luteum. Bogan RL, Murphy MJ, Hennebold JD. Endocrinology. 2009 150:1521-9.
[PubMed:18948396]
[PMC:PMC2654732]
3
Aromatase expression in human peripheral blood leucocytes (PBLs) and in various tissues in primates: studies in elderly humans and cynomolgus monkeys. Pignatti E, Casarini L, Scaltriti S, Wistuba J, Schlatt S, Rossi A, Lachhab A, Taliani E, Carani C, Simoni M. Journal of medical primatology. 2012 41:372-83. (WB; Human, Primate)
[PubMed:22978812]
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CYP19 / Aromatase
(83)
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(52)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(79)
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(13)
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(7)
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(4)
CYP19 / Aromatase Goat anti-Human Polyclonal (aa475-486) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CYP19 / Aromatase Rabbit anti-Human Polyclonal (aa400-502) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
CYP19 / Aromatase Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Human, Primate
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
CYP19 / Aromatase Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
CYP19 / Aromatase Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
CYP19 / Aromatase Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
CYP19 / Aromatase Rabbit anti-Human Polyclonal (aa221-270) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CYP19 / Aromatase Mouse anti-Human Monoclonal (aa376-390) (Concentrated) (H4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated, Concentrated
1 ml/$932
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
CYP19 / Aromatase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
CYP19 / Aromatase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYP19 / Aromatase Rabbit anti-Human Polyclonal (190-270 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP19 / Aromatase Rabbit anti-Human Polyclonal (Lys243) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Sandwich
96-Well Strip Plate
Rat
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His
22.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
CYP19 / Aromatase Rabbit anti-Human Polyclonal (aa485-503) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CYP19 / Aromatase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
CYP19 / Aromatase Rabbit anti-Human Polyclonal (aa453-485) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CYP19 / Aromatase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
CYP19 / Aromatase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
CYP19 / Aromatase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$649
CYP19 / Aromatase Rabbit anti-Oryzias latipes Polyclonal (C-Terminus) Antibody
Oryzias latipes
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
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