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CYP17 / CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
CYP17 / CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
| Gene Name: | cytochrome P450, family 17, subfamily A, polypeptide 1 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP17A1, CYP17, CYPXVII, CPT7, Cytochrome P450-C17, Cytochrome P450c17, p450C17, Steroid 17-alpha-monooxygenase, Cytochrome P450 17A1, Cytochrome p450 XVIIA1, S17AH |
| Target Sequences: | NM_000102 NP_000093.1 P05093 |
Publications (7)
1
Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes. Kitamura S, Abiko K, Matsumura N, Nakai H, Akimoto Y, Tanimoto H, Konishi I. Journal of gynecologic oncology. 2017 28:e31. (ICC; Human)
[Full Text Article]
[PubMed:28541629]
[PMC:PMC5447140]
2
EB 2017 Article: Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Ronis MJ, Gomez-Acevedo H, Shankar K, Sharma N, Blackburn M, Singhal R, Mercer KE, Badger TM. Experimental biology and medicine (Maywood, N.J.). 2018 May;243:695-707. [Full Text Article]
[PubMed:29763383]
[PMC:PMC6378512]
3
Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas. Juilee Rege, Kazutaka Nanba, Amy R Blinder, Samuel Plaska, Aaron M Udager, Pankaj Vats, Chandan Kumar-Sinha, Thomas J Giordano, William E Rainey, Tobias Else. Journal of the Endocrine Society. 2020 October;4:bvaa123. [Full Text Article]
[PubMed:33033789]
[PMC:PMC7528565]
Related Antibodies: LS-B14227.
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CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa358-388) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
CYP17 / CYP17A1 Goat anti-Human Polyclonal (aa134-144) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa1-508) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CYP17 / CYP17A1 Mouse anti-Human Monoclonal (OTI3F11) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYP17 / CYP17A1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3F11) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (190-270 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (Asn249) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa24-508) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa24-508) (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated
50 µg/$294; 100 µg/$360
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa24-508) (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$294; 100 µg/$360
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal (aa24-508) (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
50 µg/$294; 100 µg/$360
CYP17 / CYP17A1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Human
Flo, IHC-P, WB
Unconjugated
100 µg/$575
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
CYP17 / CYP17A1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CYP17 / CYP17A1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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