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CYBB / NOX2 / gp91phox

cytochrome b-245, beta polypeptide

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene Name: cytochrome b-245, beta polypeptide
Synonyms: CYBB, Chronic granulomatous disease, CGD91-phox, Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, gp91-1, gp91-PHOX, p22 phagocyte B-cytochrome, AMCBX2, CGD, Cytochrome b-245 heavy chain, gp91PHOX, NADPH oxidase 2, NOX2, p91-PHOX
Target Sequences: NM_000397 NP_000388.2 P04839

Publications (10)

1
Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. Trocme C, Deffert C, Cachat J, Donati Y, Tissot C, Papacatzis S, Braunersreuther V, Pache JC, Krause KH, Holmdahl R, Barazzone-Argiroffo C, Carnesecchi S. The Journal of pathology. 2015 235:65-78. (WB; Human) [Full Text Article] [PubMed:25116588] [PMC:PMC4280678]
2
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P. Scientific reports. 2016 6:32554. (IHC; Human) [Full Text Article] [PubMed:27624556] [PMC:PMC5021994]
3
Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse. Seredenina T, Sorce S, Herrmann FR, Ma Mulone XJ, Plastre O, Aguzzi A, Jaquet V, Krause KH. Translational psychiatry. 2017 August;7:e1206. [Full Text Article] [PubMed:28809856] [PMC:PMC5611741]
4
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive. Keszei M, Record J, Kritikou JS, Wurzer H, Geyer C, Thiemann M, Drescher P, Brauner H, Köcher L, James J, He M, Baptista MA, Dahlberg CI, Biswas A, Lain S, Lane DP, Song W, Pütsep K, Vandenberghe P, Snapper SB, Westerberg LS. The Journal of clinical investigation. 2018 August;128:4115-4131. [Full Text Article] [PubMed:30124469] [PMC:PMC6118594] Related Antibodies: LS-C179418.
5
Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR. Becky A Diebold, S Garrett Wilder, Xavier De Deken, Jennifer L Meitzler, James H Doroshow, James W McCoy, Yerun Zhu, J David Lambeth. Methods in molecular biology (Clifton, N.J.). 2019 June;1982:191-229. [Full Text Article] [PubMed:31172474] [PMC:PMC8132109] Related Antibodies: LS-C179418.
6
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects. Katie Frenis, Johanna Helmstädter, Yue Ruan, Eva Schramm, Sanela Kalinovic, Swenja Kröller-Schön, Maria Teresa Bayo Jimenez, Omar Hahad, Matthias Oelze, Subao Jiang, Philip Wenzel, Clemens J Sommer, Katrin B M Frauenknecht, Ari Waisman, Adrian Gericke, Andreas Daiber, Thomas Münzel , Sebastian Steven. Basic research in cardiology. 2021 April;116:31. [Full Text Article] [PubMed:33929610] [PMC:PMC8087569] Related Antibodies: LS-B12365.
7
High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing. Duran Sürün, Joachim Schwäble, Ana Tomasovic, Roy Ehling, Stefan Stein, Nina Kurrle, Harald von Melchner, Frank Schnütgen. Molecular therapy. Nucleic acids. 2018 March;10:44409. [Full Text Article] [PubMed:29499925] [PMC:PMC5723376]
8
GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation. Johanna Helmstädter, Karin Keppeler, Franziska Aust, Leonie Küster, Katie Frenis, Konstantina Filippou, Ksenija Vujacic-Mirski, Simeon Tsohataridis, Sanela Kalinovic, Swenja Kröller-Schön, Matthias Oelze, Markus Bosmann , Thomas Münzel , Andreas Daiber , Sebastian Steven. Antioxidants. 2021 Jul;10:1175. [Full Text Article] [PubMed:34439423] [PMC:PMC8388926] Related Antibodies: LS-B12365.
9
Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development. Katie Frenis, Sanela Kalinovic, Benjamin P Ernst, Miroslava Kvandova, Ahmad Al Zuabi, Marin Kuntic, Matthias Oelze, Paul Stamm, Maria Teresa Bayo Jimenez, Agnieszka Kij, Karin Keppeler, Veronique Klein, Lea Strohm, Henning Ubbens, Steffen Daub, Omar Hahad, Swenja Kröller-Schön, Michael J Schmeisser, Stefan Chlopicki, Jonas Eckrich, Sebastian Strieth, Andreas Daiber, Sebastian Steven, Thomas Münzel. Frontiers in molecular biosciences. 2022 February;8:814921. [Full Text Article] [PubMed:35174211] [PMC:PMC8841864] Related Antibodies: LS-B12365.
10
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Priya Rangan, Fleur Lobo, Edoardo Parrella, Nicolas Rochette, Marco Morselli, Terri-Leigh Stephen, Anna Laura Cremonini, Luca Tagliafico, Angelica Persia, Irene Caffa, Fiammetta Monacelli, Patrizio Odetti, Tommaso Bonfiglio, Alessio Nencioni, Martina Pigliautile, Virginia Boccardi, Patrizia Mecocci, Christian J Pike, Pinchas Cohen, Mary Jo LaDu, Matteo Pellegrini, Kyle Xia, Katelynn Tran, Brandon Ann, Dolly Chowdhury, Valter D Longo. Cell reports. 2022 September;40:111417. [Full Text Article] [PubMed:36170815] [PMC:PMC9648488]
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CYBB / NOX2 / gp91phox (5)
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CYBB / NOX2 / gp91phox Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Human CYBB / NOX2 / gp91phox Protein (Recombinant 6His, N-terminus) (aa283-570) - LS-G56198
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CYBB / NOX2 / gp91phox Protein - Recombinant Cytochrome b-245 Beta Polypeptide By SDS-PAGE
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Human CYBB / NOX2 / gp91phox Protein (Recombinant His, N-Terminal) (aa283-570) - LS-G25251
E. coli
His, N-Terminal
36.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
CYBB / NOX2 / gp91phox Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human CYBB / NOX2 / gp91phox Protein (Recombinant GST, N-terminus) (aa120-171) - LS-G58269
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CYBB / NOX2 / gp91phox Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human CYBB / NOX2 / gp91phox Protein (Recombinant 6His, N-terminus) (aa283-570) - LS-G57153
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CYBB / NOX2 / gp91phox Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human CYBB / NOX2 / gp91phox Protein (Recombinant 6His-SUMO, N-terminus) (aa283-570) - LS-G56199
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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