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Cytochrome b is composed of cytochrome b alpha (CYBA; flavocytochrome b-558) and beta (CYBB; flavocytochrome b-245) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBA deficiency is associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Gene Name: | cytochrome b-245, alpha polypeptide |
Synonyms: | CYBA, Cytochrome b(558) alpha chain, Cytochrome b-245 light chain, Cytochrome b558 subunit alpha, p22 phagocyte B-cytochrome, p22-PHOX, Cytochrome b light chain, p22phox |
Target Sequences: | NM_000101 NP_000092.2 P13498 |
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