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CX3CR1

chemokine (C-X3-C motif) receptor 1

CX3CR1 a Chemokine Receptor is an HIV coreceptor, as well as a leukocyte chemotactic/adhesion receptor for fractalkine, also known as neurotactin. CX3CR1 mediates chemotactic responses to the soluble form of fractalkine in neutrophils and T cells, and cytoadhesion to cells expressing membrane-anchored fractalkine, such as monocytes, T cells, and neutrophils. Cells transfected with CX3CR1 exhibited chemotaxis and transient increases in intracellular calcium concentration when exposed to fractalkine.

Gene Name: chemokine (C-X3-C motif) receptor 1
Family/Subfamily: GPCR , Chemokine
Synonyms: CX3CR1, Beta chemokine receptor-like 1, C-X3-C CKR-1, Chemokine (C-X3-C) receptor 1, CMKBRL1, CMK-BRL-1, CMKDR1, CMK-BRL1, CX3C chemokine receptor 1, Fkn receptor, GPR13, GPRV28, Fractalkine receptor, G protein-coupled receptor v28, G-protein coupled receptor 13, V28, Chemokine c-x3-c receptor 1, G protein-coupled receptor 13
Target Sequences: NM_001337 NP_001328.1 P49238

Publications (2)

1
Up-regulation of CX3CR1 on tonsillar CD8-positive cells in patients with IgA nephropathy. Otaka R, Takahara M, Ueda S, Nagato T, Kishibe K, Nomura K, Katada A, Hayashi T, Harabuchi Y. Human immunology. 2017 78:375-383. (IHC; Human) [Full Text Article] [PubMed:28196748] Related Antibodies: LS-A86.
2
High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation. Szukiewicz D, Pyzlak M, Szewczyk G, Stangret A, Trojanowski S, Bachanek M, Braksator W, Wejman J. Mediators of inflammation. 2017 2017:9853108. [Full Text Article] [PubMed:28655972] [PMC:PMC5471565]

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CX3CR1 (5)
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CX3CR1 Protein - 12.5% SDS-PAGE of human CX3CR1 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.79 kDa
2 µg/$439
CX3CR1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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HEK 293 Cells
His, N-Terminal
~40 kDa
200 µl/$283
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HEK 293 Cells
His, N-Terminal
~40 kDa
100 µg/$298
CX3CR1 Protein - 12.5% SDS-PAGE of human CX3CR1 stained with Coomassie Blue
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Wheat Germ Extract
GST
66.8 kDa
2 µg/$439
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).