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CUL5 / Cullin-5
cullin 5
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
| Gene Name: | cullin 5 |
| Family/Subfamily: | Ion Channel |
| Synonyms: | CUL5, Cullin 5, CUL-5, VACM-1, VACM1, Cullin-5 |
| Target Sequences: | NM_003478 NP_003469.2 Q93034 |
Publications (2)
1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39.
[PubMed:8681378]
Related Antibodies: LS-B361.
2
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Ohta T, Michel JJ, Schottelius AJ, Xiong Y. Molecular cell. 1999 3:535-41.
[PubMed:10230407]
Related Antibodies: LS-B361.
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CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa1-25) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa747-774) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IF, IHC, IHC-P
Unconjugated
100 µl/$470
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa1-300) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa1-300) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa4-19) Antibody
Xenopus, Zebrafish, Horse, Rat, Hamster, Rabbit, Mouse, Bovine, Human, Monkey
ELISA, ICC, WB
Unconjugated
1 mg/$901
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$357
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa526-575) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa526-575) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
HRP Conjugated
100 µl/$442
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa526-575) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
CUL5 / Cullin-5 Rabbit anti-Human Polyclonal (aa526-575) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$442
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
90.8 kDa
20 µg/$1,107
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HEK 293 Cells
Myc-DDK (Flag)
90.8 kDa
100 µg/$494
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