CUL2 / Cullin 2

cullin 2

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CUL2 / Cullin 2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CUL2 / Cullin 2 Protein (Recombinant GST) (Full Length) - LS-G31160

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

113.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CUL2 / Cullin 2 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G60728

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CUL2 / Cullin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75329

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.8 kDa

Price:

20 µg/$150

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Human CUL2 / Cullin 2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65318

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.8 kDa

Price:

20 µg/$1,107

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CUL2 / Cullin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117216

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.8 kDa

Price:

100 µg/$494

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