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CUL2 / Cullin 2
cullin 2
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
| Gene Name: | cullin 2 |
| Synonyms: | CUL2, Cullin homolog 2, CUL-2, Cullin 2, Cullin-2 |
| Target Sequences: | NM_003591 NP_003582.2 Q13617 |
Publications (2)
1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39.
[PubMed:8681378]
Related Antibodies: LS-B358.
2
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt EK, Kipreos ET. Nature cell biology. 1999 1:486-92.
[PubMed:10587644]
Related Antibodies: LS-B358.
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CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa696-745) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa720-745) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
CUL2 / Cullin 2 Goat anti-Human Polyclonal (aa748-759) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (670-750 aa, C-terminal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (Ile726) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Wheat Germ Extract
GST
113.4 kDa
10 µg/$479; 25 µg/$670
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
100 µl/$386
![CUL2 / Cullin 2 Antibody - Immunofluorescence of monoclonal antibody to CUL2 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/cul2-cullin-2-antibody-clone-4g11-ls-c198566/147182_4866076.jpg)
CUL2 / Cullin 2 Mouse anti-Human Monoclonal (4G11) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$914
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa264-280) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Guinea pig, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IHC, IP
Unconjugated
10 µg/$295; 100 µl/$514
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa733-745) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human, Monkey
ELISA, WB
Unconjugated
1 mg/$901
CUL2 / Cullin 2 Rabbit anti-Human Polyclonal (aa150-179) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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