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CUBN / Cubilin

cubilin (intrinsic factor-cobalamin receptor)

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

Gene Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: CUBN, 460 kDa receptor, Cubilin, Cubilin precursor variant 1, Cubilin precursor variant 2, gp280, MGA1, IFCR
Target Sequences: NM_001081 NP_001072.2 O60494

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
CUBN / Cubilin (9)
No (9)
His (5)
His, N-Terminal (2)
Myc-DDK (Flag) (2)
Human (3)
Mouse (2)
Rat (3)
293T Cells (1)
E. coli (7)
HEK 293 Cells (1)
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
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E. coli
His, N-Terminal
14.4 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
Select
E. coli
His
13.6 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
Select
E. coli
His
14.4 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
Select
E. coli
His, N-Terminal
13.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
Select
E. coli
His
14.4 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
Select
E. coli
His
13.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
CUBN / Cubilin Protein - Recombinant Cubilin By SDS-PAGE
Select
E. coli
His
13.7 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
CUBN / Cubilin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
398.6 kDa
20 µg/$215
CUBN / Cubilin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
398.6 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).