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CTTN / Cortactin

cortactin

CTTN / Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Gene Name: cortactin
Synonyms: CTTN, Cortactin, EMS1, Oncogene EMS1, Amplaxin, Src substrate cortactin
Target Sequences: NM_005231 NP_005222.2 Q14247

Publications (2)

1
Overexpression and Tyr421-phosphorylation of cortactin is induced by three-dimensional spheroid culturing and contributes to migration and invasion of pancreatic ductal adenocarcinoma (PDAC) cells. Stock K, Borrink R, Mikesch JH, Hansmeier A, Rehkämper J, Trautmann M, Wardelmann E, Hartmann W, Sperveslage J, Steinestel K. Cancer cell international. 2019 March;19:77. [Full Text Article] [PubMed:30976201] [PMC:PMC6441202]
2
The Pathogenic Effect of Cortactin Tyrosine Phosphorylation in Cutaneous Squamous Cell Carcinoma. Zhu L#, Cho E#, Zhao G, Roh MR, Zheng Z. In Vivo. 2019 March-Apri;33:393-400. [Full Text Article] [PubMed:30804117] [PMC:PMC6506328] Related Antibodies: LS-C353975, LS-C381441.

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ELISA Kits (3)
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CTTN / Cortactin (3)
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CTTN / Cortactin ELISA Kit
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Cell-Based
96-Well Microplate
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Colorimetric - 450nm (TMB)
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1 Plate/$534
CTTN / Cortactin ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
2 Plates/$668
CTTN / Cortactin ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
2 Plates/$668
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).