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CTSL / Cathepsin L

Cathepsin L

CTSL / Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: Cathepsin L
Family/Subfamily: Protease , Cysteine C1
Synonyms: CTSL, Cathepsin L, Cathepsin L1, CATL, CTSL1, Major excreted protein, MEP
Target Sequences: NM_001912 NP_001903.1 P07711

Publications (1)

1
Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine. Palanikumar Gunasekar, Mohan Satish, Parinaz Dabestani, Wanlin Jiang, Chandra Boosani, Mohammad Radwan, Devendra Agrawal, Juan Asensio. The Journal of surgical research. 2019 November;243:460-468. [Full Text Article] [PubMed:31377485] [PMC:PMC6773494] Related Antibodies: LS-C293267.

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Antibodies (117)
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CTSL / Cathepsin L (170)
Human (85)
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CTSL / Cathepsin L Antibody - Western Blot; Sample: Recombinant protein.
Select
CTSL / Cathepsin L Rabbit anti-Pig Polyclonal (aa115-288) Antibody
Pig
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
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CTSL / Cathepsin L Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µl/$550
CTSL / Cathepsin L ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
CTSL / Cathepsin L Antibody - Anti-CTSL1 / Cathepsin L antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CTSL / Cathepsin L Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CTSL / Cathepsin L Antibody - Anti-CTSL / Cathepsin L antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CTSL / Cathepsin L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CTSL / Cathepsin L Antibody - Western blot analysis of extracts of various cell lines, using CTSL antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
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CTSL / Cathepsin L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CTSL / Cathepsin L ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CTSL / Cathepsin L ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
CTSL / Cathepsin L ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
CTSL / Cathepsin L Antibody - Anti-CTSL1 / Cathepsin L antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CTSL / Cathepsin L Mouse anti-Human Monoclonal (aa114-333) (2H7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
CTSL / Cathepsin L Rabbit anti-Mouse Polyclonal (aa267-294) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
CTSL / Cathepsin L Antibody - Western blot of extracts from HeLa cells, treated with etoposide 25 uM 1h, using CATL1 (heavy chain, Cleaved-Thr288) Antibody. The lane on the right is treated with the synthesized peptide.
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CTSL / Cathepsin L Rabbit anti-Human Polyclonal (aa239-288) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CTSL / Cathepsin L Antibody - Western blot of recombinant CTSL / Cathepsin L.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CTSL / Cathepsin L Rabbit anti-Mouse Polyclonal (aa18-113) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
Select
CTSL / Cathepsin L Rabbit anti-C. elegans Polyclonal Antibody
C. elegans
WB
Unconjugated
50 µg/$440; 100 µg/$480
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CTSL / Cathepsin L Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$564
CTSL / Cathepsin L Antibody - CTSL / Cathepsin L antibody Western Blot of HT1080.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CTSL / Cathepsin L Rabbit anti-Human Polyclonal (aa194-243) (Biotin) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
CTSL / Cathepsin L Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using CTSL Antibody at dilution of 1:100
Select
CTSL / Cathepsin L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
CTSL / Cathepsin L ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His, N-Terminal
20.3 kDa; Observed: 20.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
CTSL / Cathepsin L Protein - Recombinant Cathepsin L By SDS-PAGE
Select
E. coli
His
20.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.88kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
CTSL / Cathepsin L Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-CTSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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CTSL / Cathepsin L Mouse anti-Human Monoclonal (aa114-333) (Carrier-free) (OTI1C7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CTSL / Cathepsin L Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-CTSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
CTSL / Cathepsin L Mouse anti-Human Monoclonal (aa114-333) (Carrier-free) (OTI2C10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CTSL / Cathepsin L Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-CTSL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
CTSL / Cathepsin L Mouse anti-Human Monoclonal (aa114-333) (Carrier-free) (OTI6D5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CTSL / Cathepsin L Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-CTSL1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
Select
CTSL / Cathepsin L Mouse anti-Human Monoclonal (OTI2H2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
Viewing 1-25 of 170 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).