CTSF / Cathepsin F

cathepsin F

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CTSF / Cathepsin F (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human CTSF / Cathepsin F Protein (Recombinant 6His, N-terminus) (aa273-484) - LS-G22663

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse CTSF / Cathepsin F Protein (Recombinant His, N-Terminal) (Ala249-Asn462) - LS-G133463

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

27.3kDa

Price:

10 µg/$276; 50 µg/$412; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human CTSF / Cathepsin F Protein (Recombinant GST) (Full Length) - LS-G31296

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

79.8 kDa

Price:

2 µg/$439

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Human CTSF / Cathepsin F Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82509

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.2 kDa

Price:

20 µg/$150

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CTSF / Cathepsin F Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117085

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.2 kDa

Price:

100 µg/$494

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Human CTSF / Cathepsin F Protein (Recombinant His) - LS-G2478

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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