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CTSC / Cathepsin C / JP
cathepsin C
CTSC / Cathepsin C / JP, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | cathepsin C |
| Family/Subfamily: | Protease , Cysteine C1 |
| Synonyms: | CTSC, Cathepsin J, Dipeptidyl peptidase 1, Dipeptidyl peptidase I, DPP-I, Dipeptidyl transferase, Dipeptidyl-peptidase I, CPPI, DPPI, DPP1, HMS, JP, PDON1, PLS, JPD, Cathepsin C, PALS |
| Target Sequences: | NM_001814 NP_001805.3 P53634 |
Publications (1)
1
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Carcinogenesis. 2015 November;36:1263-1274. [Full Text Article]
[PubMed:26354777]
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CTSC / Cathepsin C / JP
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CTSC / Cathepsin C / JP Goat anti-Human Polyclonal (aa238-252) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CTSC / Cathepsin C / JP Rabbit anti-Bovine Polyclonal Antibody
Bovine
ELISA, IF, IHC, WB
Unconjugated
1 mg/$520
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CTSC / Cathepsin C / JP Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (aa151-200) Antibody
Human
WB
Unconjugated
100 µl/$424
CTSC / Cathepsin C / JP Rabbit anti-Bovine Polyclonal Antibody
Bovine
ELISA, IF, IHC, WB
Unconjugated
10 mg/$335
CTSC / Cathepsin C / JP Rabbit anti-Bovine Polyclonal (Biotin) Antibody
Bovine
ELISA, IF, IHC, WB
Biotin Conjugated
1 ml/$438
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
His
27.2 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (320-400 aa, C-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (heavy chain, Cleaved-Arg394) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (aa345-394) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CTSC / Cathepsin C / JP Rabbit anti-Mouse Polyclonal (aa231-462) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (aa185-234) Antibody
Human
WB
Unconjugated
100 µl/$424
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Human
WB
Unconjugated
100 µl/$299
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Human
WB
Unconjugated
100 µl/$299
CTSC / Cathepsin C / JP Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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