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CTNND1 / p120 Catenin

catenin (cadherin-associated protein), delta 1

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Gene Name: catenin (cadherin-associated protein), delta 1
Family/Subfamily: Catenin , not assigned-Catenin
Synonyms: CTNND1, CAS, Catenin delta-1, CTNND, KIAA0384, p120, p120(CAS), p120(CTN), p120CAS, p120CTN, p120 catenin, p120-catenin
Target Sequences: NM_001331 NP_001322.1 O60716

Publications (2)

1
P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells. Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y. The Journal of dermatology. 2008 35:317-24. (ICC, IP) [PubMed:18578707]
2
Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Petrova YI, Spano MM, Gumbiner BM. Molecular biology of the cell. 2012 23:2092-108. (IF) [PubMed:22513089] [PMC:PMC3364174]

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Proteins (8)
Over-Expression Lysate (6)
Recombinant (2)
CTNND1 / p120 Catenin (8)
No (8)
GST, N-terminus (1)
Myc-DDK (Flag) (7)
Human (5)
293T Cells (3)
HEK 293 Cells (4)
Wheat Germ Extract (1)
CTNND1 / p120 Catenin Protein - Purified recombinant protein CTNND1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
108 kDa
20 µg/$1,107
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
104 kDa
20 µg/$215
CTNND1 / p120 Catenin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
108.2 kDa
100 µg/$710
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
104 kDa
100 µg/$710
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
92.5 kDa
100 µg/$710
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
108.2 kDa
20 µg/$215
CTNND1 / p120 Catenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
92.5 kDa
20 µg/$215
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).