CTNNA1 / Catenin Alpha-1

Catenin (Cadherin-associated Protein), Alpha 1, 102kDa

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CTNNA1 / Catenin Alpha-1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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CTNNA1 / Catenin Alpha-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99593

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

100 µg/$494

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Human CTNNA1 / Catenin Alpha-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64894

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

20 µg/$1,107

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Human CTNNA1 / Catenin Alpha-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74418

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

20 µg/$150

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Human CTNNA1 / Catenin Alpha-1 Protein (Recombinant His-T7) (aa2-228) - LS-G24683

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human CTNNA1 / Catenin Alpha-1 Protein (Recombinant GST) (Full Length) - LS-G28094

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

85.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CTNNA1 / Catenin Alpha-1 Protein (Recombinant GST, N-terminus) (aa152-250) - LS-G58255

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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