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CTNNA1 / Catenin Alpha-1
Catenin (Cadherin-associated Protein), Alpha 1, 102kDa
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
| Gene Name: | Catenin (Cadherin-associated Protein), Alpha 1, 102kDa |
| Family/Subfamily: | Catenin , not assigned-Catenin |
| Synonyms: | CTNNA1, AlphaE-catenin, Alpha-E-catenin, Alpha(E)-catenin, Alpha-1 catenin, Alpha-catenin, Cadherin-associated protein, Alpha E-catenin, CAP102, Catenin alpha-1 |
| Target Sequences: | NM_001903 NP_001894.2 P35221 |
Publications (2)
1
Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice. Christensen IB, Gyldenholm T, Damkier HH, Praetorius J. Frontiers in physiology. 2013 4:344. (IHC; Mouse)
[Full Text Article]
[PubMed:24348423]
[PMC:PMC3842056]
Related Antibodies: LS-B4457.
2
Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium. Christensen IB, Wu Q, Bohlbro AS, Skals MG, Damkier HH, Hübner CA, Fenton RA, Praetorius J. Fluids and barriers of the CNS. 2020 January;17:2. [Full Text Article]
[PubMed:31906971]
[PMC:PMC6945596]
Related Antibodies: LS-B4457.
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CTNNA1 / Catenin Alpha-1 Goat anti-Human Polyclonal (aa871-883) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (aa30-59) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$440
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$287; 100 µl/$431
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (C-Terminus) (7A4) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$801
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (HRP) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
HRP Conjugated
100 µl/$1,027
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (Biotin) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,027
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (FITC) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
FITC Conjugated
100 µl/$1,027
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (APC) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
APC Conjugated
100 µl/$1,027
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (PE) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
PE Conjugated
100 µl/$1,027
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (830-910 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTNNA1 / Catenin Alpha-1 Mouse anti-Mouse Monoclonal (alpha-CAT-7A4) Antibody
Mouse
ELISA, IF, IHC-P, IP, WB
Unconjugated
50 µg/$502
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (aa143-292) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CTNNA1 / Catenin Alpha-1 Mouse anti-Human Monoclonal Antibody
Mouse, Dog, Rat, Human
ELISA, ICC, IP, WB
Unconjugated
50 µg/$518; 100 µg/$854
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
HEK 293 Cells
Myc-DDK (Flag)
99.9 kDa
100 µg/$494
CTNNA1 / Catenin Alpha-1 Mouse anti-Human Monoclonal (8B6C1) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
CTNNA1 / Catenin Alpha-1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
CTNNA1 / Catenin Alpha-1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Xenopus, Chicken, Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$801
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (580-660 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (580-660 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CTNNA1 / Catenin Alpha-1 Rabbit anti-Human Polyclonal (aa607-656) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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