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Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Gene Name: | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
Synonyms: | CTDSP1, NIF3, NLIIF, NLI-IF, SCP1, NLI-interacting factor 3, Small CTD phosphatase 1 |
Target Sequences: | NM_021198 NP_067021.1 Q9GZU7 |
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